While low profile tires look great and offer tremendous handling advantages, care needs to be taken when driving. Hazards, such as potholes can cause serious tire and wheel damage; damage that might otherwise not occur on regular tires & wheels.
The picture below shows a cracked wheel and damaged tire on a 2004 Jaguar X-type wagon. While the crack in this wheel looks catastrophic it was repairable. The tire unfortunately required replacement due to sidewall damage from being run on low air pressure.
If you own a vehicle with low profile tires be careful with road hazards: they may lead to very expensive repairs.